<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:9ad61a15-e285-44cc-ad2a-44a040d7fb22,g:5f0dd9b0-b13f-4c69-b05c-880a09202ba6-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://darebioscience.com/role/CoverPage" xlink:type="simple" xlink:href="dare-20200930.xsd#CoverPage"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/CoverPage" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="dare-20200930.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_8d926af7-4bb9-4ede-9518-df954111b93f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_a9790ec2-6804-4b8c-a6e6-0e0487d25e86" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d926af7-4bb9-4ede-9518-df954111b93f" xlink:to="loc_us-gaap_PreferredStockValue_a9790ec2-6804-4b8c-a6e6-0e0487d25e86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_6f2d440d-3fa9-49c9-8dac-9a6c713dbe45" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d926af7-4bb9-4ede-9518-df954111b93f" xlink:to="loc_us-gaap_CommonStockValue_6f2d440d-3fa9-49c9-8dac-9a6c713dbe45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_397f4ca5-9b68-41fc-b7e9-2196cae359ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d926af7-4bb9-4ede-9518-df954111b93f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_397f4ca5-9b68-41fc-b7e9-2196cae359ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_30c7741f-4376-4823-92db-af1156c0856b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d926af7-4bb9-4ede-9518-df954111b93f" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_30c7741f-4376-4823-92db-af1156c0856b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_58589fcd-4718-4511-8808-e5641fc17000" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_8d926af7-4bb9-4ede-9518-df954111b93f" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_58589fcd-4718-4511-8808-e5641fc17000" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_afce41ea-c717-4208-bb23-dd9d3145151d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_2d2563f6-8684-4251-91f1-55b9812af946" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_afce41ea-c717-4208-bb23-dd9d3145151d" xlink:to="loc_us-gaap_AssetsCurrent_2d2563f6-8684-4251-91f1-55b9812af946" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_1cbbab3f-8b85-4859-9f52-7931eebcb2b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_afce41ea-c717-4208-bb23-dd9d3145151d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_1cbbab3f-8b85-4859-9f52-7931eebcb2b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_084bb2f1-40c5-47eb-862c-960d8ea7a702" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_afce41ea-c717-4208-bb23-dd9d3145151d" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_084bb2f1-40c5-47eb-862c-960d8ea7a702" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_8dd7edec-74c7-4c80-a5ed-ee7e4ddd07dc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_e642f795-03f5-4ac0-9691-fc6387d37f0c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8dd7edec-74c7-4c80-a5ed-ee7e4ddd07dc" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_e642f795-03f5-4ac0-9691-fc6387d37f0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_229972dd-bb64-4b0d-a196-9bff4130f435" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8dd7edec-74c7-4c80-a5ed-ee7e4ddd07dc" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_229972dd-bb64-4b0d-a196-9bff4130f435" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c36a64f0-0ffc-4eb1-9b2f-ff91f4a1e105" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_8dd7edec-74c7-4c80-a5ed-ee7e4ddd07dc" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c36a64f0-0ffc-4eb1-9b2f-ff91f4a1e105" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_f7b7157b-2e32-4d5a-a60f-0160c9b97ef2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_b1f14890-43b1-4d62-9171-fe2213ffb7f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f7b7157b-2e32-4d5a-a60f-0160c9b97ef2" xlink:to="loc_us-gaap_Liabilities_b1f14890-43b1-4d62-9171-fe2213ffb7f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_be051ee0-a24d-4555-a179-c9e9a9c8541a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f7b7157b-2e32-4d5a-a60f-0160c9b97ef2" xlink:to="loc_us-gaap_CommitmentsAndContingencies_be051ee0-a24d-4555-a179-c9e9a9c8541a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_07accff3-224b-4eb0-bf13-0358d7482393" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f7b7157b-2e32-4d5a-a60f-0160c9b97ef2" xlink:to="loc_us-gaap_StockholdersEquity_07accff3-224b-4eb0-bf13-0358d7482393" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_ddfebc9a-55c3-4b55-9430-b73ed660ae98" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_4b616833-8ac2-4669-911a-3b8e78fe23aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ddfebc9a-55c3-4b55-9430-b73ed660ae98" xlink:to="loc_us-gaap_AccountsPayableCurrent_4b616833-8ac2-4669-911a-3b8e78fe23aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_4db274e6-a4a6-4606-bd77-da0619e8f1ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ddfebc9a-55c3-4b55-9430-b73ed660ae98" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_4db274e6-a4a6-4606-bd77-da0619e8f1ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DeferredGrantFundingCurrent_e97cd7de-30ea-4a88-8b83-71bdcff77e13" xlink:href="dare-20200930.xsd#dare_DeferredGrantFundingCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ddfebc9a-55c3-4b55-9430-b73ed660ae98" xlink:to="loc_dare_DeferredGrantFundingCurrent_e97cd7de-30ea-4a88-8b83-71bdcff77e13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_b4548ea9-b5a4-4d4e-991d-eb854def8ec8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ddfebc9a-55c3-4b55-9430-b73ed660ae98" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_b4548ea9-b5a4-4d4e-991d-eb854def8ec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent_44bcdb55-9294-465d-93e9-3bc3ef4191e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesPayableCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ddfebc9a-55c3-4b55-9430-b73ed660ae98" xlink:to="loc_us-gaap_NotesPayableCurrent_44bcdb55-9294-465d-93e9-3bc3ef4191e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_2c4791c3-91e3-4b34-aa60-6dc67e1f5698" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_ddfebc9a-55c3-4b55-9430-b73ed660ae98" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_2c4791c3-91e3-4b34-aa60-6dc67e1f5698" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_51a32ab9-1c0c-48f2-b62f-7b26598c5f8b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_5a6dbd79-8f92-4c86-9cae-af0e4cbe9497" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_51a32ab9-1c0c-48f2-b62f-7b26598c5f8b" xlink:to="loc_us-gaap_LiabilitiesCurrent_5a6dbd79-8f92-4c86-9cae-af0e4cbe9497" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_fa918b8d-61e2-4054-8af3-cff903850051" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_51a32ab9-1c0c-48f2-b62f-7b26598c5f8b" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_fa918b8d-61e2-4054-8af3-cff903850051" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_412c0419-b123-4302-9406-58dbb273a12d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_51a32ab9-1c0c-48f2-b62f-7b26598c5f8b" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_412c0419-b123-4302-9406-58dbb273a12d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_637cd91d-c577-4c48-9768-5be47355ae23" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_51a32ab9-1c0c-48f2-b62f-7b26598c5f8b" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_637cd91d-c577-4c48-9768-5be47355ae23" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://darebioscience.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="dare-20200930.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="dare-20200930.xsd#ConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_2b908e72-7f1f-4063-9a1b-3462b7471ebe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_43427572-7fc5-4b8e-80b7-7609d4c38e76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_2b908e72-7f1f-4063-9a1b-3462b7471ebe" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_43427572-7fc5-4b8e-80b7-7609d4c38e76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f960f87f-cc9f-4d0d-8ee1-87fcc0652d03" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_2b908e72-7f1f-4063-9a1b-3462b7471ebe" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f960f87f-cc9f-4d0d-8ee1-87fcc0652d03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_a253500d-e821-4bb8-a470-ad1283346ff0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_698cae8f-75f2-4dd1-b26b-63760cfe9dc6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a253500d-e821-4bb8-a470-ad1283346ff0" xlink:to="loc_us-gaap_OperatingIncomeLoss_698cae8f-75f2-4dd1-b26b-63760cfe9dc6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_ef441f49-b018-4686-911d-08389d9ca448" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_a253500d-e821-4bb8-a470-ad1283346ff0" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_ef441f49-b018-4686-911d-08389d9ca448" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_09d77682-6427-4c9a-a561-529c81dcfb44" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_27177e38-5f76-4dd2-90c2-77086dc9a7dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_09d77682-6427-4c9a-a561-529c81dcfb44" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_27177e38-5f76-4dd2-90c2-77086dc9a7dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_92e5faa6-f0e8-446b-a992-fe2b9a397da3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_09d77682-6427-4c9a-a561-529c81dcfb44" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_92e5faa6-f0e8-446b-a992-fe2b9a397da3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseFee_c2daa3e2-111e-4cdd-a771-93204aaec19f" xlink:href="dare-20200930.xsd#dare_LicenseFee"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_09d77682-6427-4c9a-a561-529c81dcfb44" xlink:to="loc_dare_LicenseFee_c2daa3e2-111e-4cdd-a771-93204aaec19f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_1853eae7-8404-48bd-8713-6f2d8229d441" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_0ef9ca33-b862-4742-9714-5d2ad0bd5da0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_1853eae7-8404-48bd-8713-6f2d8229d441" xlink:to="loc_us-gaap_OperatingExpenses_0ef9ca33-b862-4742-9714-5d2ad0bd5da0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_7663afbc-d9e6-4e7c-b5e2-0b4291f098b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_93365b47-84f0-40b8-a592-037c4f277e00" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_7663afbc-d9e6-4e7c-b5e2-0b4291f098b9" xlink:to="loc_us-gaap_NetIncomeLoss_93365b47-84f0-40b8-a592-037c4f277e00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantDownRoundFeatureIncreaseDecreaseInEquityAmount_b65dc941-7d72-49bf-ae08-acf116b9eec3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WarrantDownRoundFeatureIncreaseDecreaseInEquityAmount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_7663afbc-d9e6-4e7c-b5e2-0b4291f098b9" xlink:to="loc_us-gaap_WarrantDownRoundFeatureIncreaseDecreaseInEquityAmount_b65dc941-7d72-49bf-ae08-acf116b9eec3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://darebioscience.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="dare-20200930.xsd#ConsolidatedStatementsofStockholdersEquity"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="dare-20200930.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d4467436-d2e0-466a-871e-039c192894bc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_489d5527-5776-4193-8cd2-2d46e81fc0eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d4467436-d2e0-466a-871e-039c192894bc" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_489d5527-5776-4193-8cd2-2d46e81fc0eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c1989795-bb85-4600-81e8-2ba19f235d11" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d4467436-d2e0-466a-871e-039c192894bc" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c1989795-bb85-4600-81e8-2ba19f235d11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_6fd4ba47-6886-495b-9998-a6e2dbe39862" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d4467436-d2e0-466a-871e-039c192894bc" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_6fd4ba47-6886-495b-9998-a6e2dbe39862" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_25024e36-eba2-4999-aac1-b9bfc77d8919" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d4467436-d2e0-466a-871e-039c192894bc" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_25024e36-eba2-4999-aac1-b9bfc77d8919" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_00725285-f638-44ba-b19d-c7050c239152" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_ProfitLoss_00725285-f638-44ba-b19d-c7050c239152" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_cd339094-b467-4270-b9e3-b3c4dc395047" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_Depreciation_cd339094-b467-4270-b9e3-b3c4dc395047" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_bc40d73f-8aad-4f28-8da5-f2010d515a19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_ShareBasedCompensation_bc40d73f-8aad-4f28-8da5-f2010d515a19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_11f1aea3-0349-4270-b70c-6f658bb15aab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherReceivables"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherReceivables_11f1aea3-0349-4270-b70c-6f658bb15aab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_be1d5ea7-ee04-4a6e-b247-5765326fcd8b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_be1d5ea7-ee04-4a6e-b247-5765326fcd8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_IncreaseDecreaseInOtherNonCurrentAssetsAndDeferredCharges_5b0d5cbd-2252-428f-90d9-b0dfe803e9b9" xlink:href="dare-20200930.xsd#dare_IncreaseDecreaseInOtherNonCurrentAssetsAndDeferredCharges"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_dare_IncreaseDecreaseInOtherNonCurrentAssetsAndDeferredCharges_5b0d5cbd-2252-428f-90d9-b0dfe803e9b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_be1ddbbb-4623-4cc9-8ef9-d8e995c8022e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_be1ddbbb-4623-4cc9-8ef9-d8e995c8022e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_1587faa5-5428-486b-8539-714b36119490" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_1587faa5-5428-486b-8539-714b36119490" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_0eeb78f6-df85-45d8-a373-e1ecf5a7affa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_0eeb78f6-df85-45d8-a373-e1ecf5a7affa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NonCashLeaseExpense_629bc128-8ad5-44f2-b8c8-ebbde04c90dc" xlink:href="dare-20200930.xsd#dare_NonCashLeaseExpense"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_dare_NonCashLeaseExpense_629bc128-8ad5-44f2-b8c8-ebbde04c90dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_IncreaseDecreaseInDeferredGrantFunding_7e646ad8-63e0-41e4-9d72-ad91cafbb909" xlink:href="dare-20200930.xsd#dare_IncreaseDecreaseInDeferredGrantFunding"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7806c5d5-0cf1-40aa-85d8-a1af4a591d70" xlink:to="loc_dare_IncreaseDecreaseInDeferredGrantFunding_7e646ad8-63e0-41e4-9d72-ad91cafbb909" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f96120e-f72c-4873-8747-03f93bd403da" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_6e71a503-1285-4500-a353-21d74e575b28" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5f96120e-f72c-4873-8747-03f93bd403da" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_6e71a503-1285-4500-a353-21d74e575b28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_07057606-d236-42ec-b65a-97a64e2555ae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NetProceedsFromIssuanceOfCommonStockAndWarrants_fb7f4452-f675-4f1e-8096-e4e69fdd2190" xlink:href="dare-20200930.xsd#dare_NetProceedsFromIssuanceOfCommonStockAndWarrants"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_07057606-d236-42ec-b65a-97a64e2555ae" xlink:to="loc_dare_NetProceedsFromIssuanceOfCommonStockAndWarrants_fb7f4452-f675-4f1e-8096-e4e69fdd2190" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromIssuanceOfCommonStockAndWarrants_b2ee9c14-98d3-417a-9597-d5f81445d8f2" xlink:href="dare-20200930.xsd#dare_ProceedsFromIssuanceOfCommonStockAndWarrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_07057606-d236-42ec-b65a-97a64e2555ae" xlink:to="loc_dare_ProceedsFromIssuanceOfCommonStockAndWarrants_b2ee9c14-98d3-417a-9597-d5f81445d8f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_ec5fc85e-b849-46df-ab6c-d47d4d8d1b95" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOrSaleOfEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_07057606-d236-42ec-b65a-97a64e2555ae" xlink:to="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_ec5fc85e-b849-46df-ab6c-d47d4d8d1b95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromNotesPayable_04ee00c3-fbae-4f7b-9b95-d04fce379ea8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromNotesPayable"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_07057606-d236-42ec-b65a-97a64e2555ae" xlink:to="loc_us-gaap_ProceedsFromNotesPayable_04ee00c3-fbae-4f7b-9b95-d04fce379ea8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://darebioscience.com/role/OrganizationandDescriptionoftheBusiness" xlink:type="simple" xlink:href="dare-20200930.xsd#OrganizationandDescriptionoftheBusiness"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/OrganizationandDescriptionoftheBusiness" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/OrganizationandDescriptionoftheBusinessAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#OrganizationandDescriptionoftheBusinessAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/OrganizationandDescriptionoftheBusinessAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="dare-20200930.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="dare-20200930.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="dare-20200930.xsd#SummaryofSignificantAccountingPoliciesTables"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#SummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#SummaryofSignificantAccountingPoliciesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/LicenseandCollaborationAgreements" xlink:type="simple" xlink:href="dare-20200930.xsd#LicenseandCollaborationAgreements"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/LicenseandCollaborationAgreements" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/LicenseandCollaborationAgreementsAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#LicenseandCollaborationAgreementsAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/LicenseandCollaborationAgreementsAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/Acquisition" xlink:type="simple" xlink:href="dare-20200930.xsd#Acquisition"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/Acquisition" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/AcquisitionNarrativeDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#AcquisitionNarrativeDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/AcquisitionNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="dare-20200930.xsd#StockBasedCompensation"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockBasedCompensation" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="dare-20200930.xsd#StockBasedCompensationTables"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockBasedCompensationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#StockBasedCompensationAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationSummaryofStockOptionActivityforAmended2014PlanandRelatedInformationDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#StockBasedCompensationSummaryofStockOptionActivityforAmended2014PlanandRelatedInformationDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockBasedCompensationSummaryofStockOptionActivityforAmended2014PlanandRelatedInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationSummaryofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#StockBasedCompensationSummaryofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockBasedCompensationSummaryofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationSummaryofAssumptionsUsedinBlackScholesOptionPricingModelforStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#StockBasedCompensationSummaryofAssumptionsUsedinBlackScholesOptionPricingModelforStockOptionsGrantedtoEmployeesandDirectorsDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockBasedCompensationSummaryofAssumptionsUsedinBlackScholesOptionPricingModelforStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquity" xlink:type="simple" xlink:href="dare-20200930.xsd#StockholdersEquity"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="dare-20200930.xsd#StockholdersEquityTables"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockholdersEquityTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#StockholdersEquityAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/LeasedProperties" xlink:type="simple" xlink:href="dare-20200930.xsd#LeasedProperties"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/LeasedProperties" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/LeasedPropertiesTables" xlink:type="simple" xlink:href="dare-20200930.xsd#LeasedPropertiesTables"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/LeasedPropertiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/LeasedPropertiesAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#LeasedPropertiesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/LeasedPropertiesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/LeasedPropertiesFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#LeasedPropertiesFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/LeasedPropertiesFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6c04afb3-f0e3-47c1-abd5-4508f9abd082" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_f1bb73ff-c58c-4561-9e06-a9b4416fda8e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6c04afb3-f0e3-47c1-abd5-4508f9abd082" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_f1bb73ff-c58c-4561-9e06-a9b4416fda8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_67a95037-ab98-439c-8c41-6d14367b4592" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_6c04afb3-f0e3-47c1-abd5-4508f9abd082" xlink:to="loc_us-gaap_OperatingLeaseLiability_67a95037-ab98-439c-8c41-6d14367b4592" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://darebioscience.com/role/LeasedPropertiesFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="dare-20200930.xsd#LeasedPropertiesFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/LeasedPropertiesFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_68cd9d40-ff20-4512-9a0a-02f5b5c0410a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_07397074-dfa3-48d0-81ff-51f2c9ffc0d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_68cd9d40-ff20-4512-9a0a-02f5b5c0410a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_07397074-dfa3-48d0-81ff-51f2c9ffc0d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_14a863e6-648a-4adf-8400-e84f85815cac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_68cd9d40-ff20-4512-9a0a-02f5b5c0410a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_14a863e6-648a-4adf-8400-e84f85815cac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_51952a40-0fed-40d4-9737-4fadf859d176" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_68cd9d40-ff20-4512-9a0a-02f5b5c0410a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_51952a40-0fed-40d4-9737-4fadf859d176" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://darebioscience.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="dare-20200930.xsd#CommitmentsandContingencies"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/CommitmentsandContingencies" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/GrantAward" xlink:type="simple" xlink:href="dare-20200930.xsd#GrantAward"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/GrantAward" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/GrantAwardNarrativeDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#GrantAwardNarrativeDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/GrantAwardNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/NetLossPerShare" xlink:type="simple" xlink:href="dare-20200930.xsd#NetLossPerShare"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/NetLossPerShare" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/NetLossPerShareTables" xlink:type="simple" xlink:href="dare-20200930.xsd#NetLossPerShareTables"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/NetLossPerShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/NetLossPerSharePotentialDilutiveOutstandingSecuritiesExcludedFromDilutedNetLossPerCommonShareDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#NetLossPerSharePotentialDilutiveOutstandingSecuritiesExcludedFromDilutedNetLossPerCommonShareDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/NetLossPerSharePotentialDilutiveOutstandingSecuritiesExcludedFromDilutedNetLossPerCommonShareDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/SubsequentEvents" xlink:type="simple" xlink:href="dare-20200930.xsd#SubsequentEvents"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/SubsequentEvents" xlink:type="extended"/>
  <link:roleRef roleURI="http://darebioscience.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="dare-20200930.xsd#SubsequentEventsDetails"/>
  <link:calculationLink xlink:role="http://darebioscience.com/role/SubsequentEventsDetails" xlink:type="extended"/>
</link:linkbase>
